| 10177 | Seekey | ZX-Spectrum 48K | English |
| 4403 | Serpenti | ZX-Spectrum 48K | English |
| 4419 | Shackled | ZX-Spectrum 48K/128K | English |
| 16161 | Sherezade | ZX-Spectrum 48K | Spanish |
| 16186 | Sigfrido | ZX-Spectrum 48K | Spanish |
| 4517 | Sinbad | ZX-Spectrum 48K | English |
| 14495 | Sir Knight | ZX-Spectrum 48K | English |
| 4553 | Skull | ZX-Spectrum 48K | English |
| 25335 | Slime Dungeon | ZX-Spectrum 16K | English |
| 23828 | Slubberdegullion | ZX-Spectrum 48K/128K | English |
| 4582 | Snackman | ZX-Spectrum 48K | English |
| 37914 | Snail Maze | ZX81 16K | English |
| 38009 | Snake | ZX-Spectrum 48K | Spanish |
| 34461 | Snake 10 | ZX-Spectrum 48K | English |
| 37062 | Snakez+ | ZX-Spectrum 48K | English |
| 34563 | Snunch | ZX81 16K | English |
| 34564 | Snunch ML | ZX81 16K | English |
| 31499 | Sophia | ZX-Spectrum 48K/128K | Multi-language: English, French, German, Italian, Portuguese, Russian, Spanish, Swedish |
| 28351 | Sophistry | SAM Coupé | English |
| 4648 | Sophistry | ZX-Spectrum 48K | English |