| 4618 | Sodov the Sorcerer | ZX-Spectrum 48K | English |
| 21247 | Soft Landing | ZX-Spectrum 48K | Russian |
| 39270 | Softly Softly Catchee Monkey | ZX-Spectrum 48K | English |
| 30597 | Software Piracy Simulator | ZX-Spectrum 16K | English |
| 4624 | Sol Negro | ZX-Spectrum 48K/128K | Spanish |
| 4626 | Solador | ZX-Spectrum 48K | English |
| 4629 | Solar Invasion | ZX-Spectrum 48K/128K | English |
| 18377 | Solar Ship | ZX-Spectrum 16K | English |
| 27094 | Solid, Liquid and Gaseous | ZX-Spectrum 48K | Spanish |
| 40483 | Solitaire | ZX81 16K | English |
| 37613 | Somewhere in Hell | ZX-Spectrum 48K | English |
| 44321 | Sonar | ZX-Spectrum 16K | English |
| 43536 | Sonic the Hedgehog and the 6 Chaos Emeralds | ZX-Spectrum 48K/128K | English |
| 22509 | Sooty & Sweep II | ZX-Spectrum 48K | English |
| 28118 | Sopapen | ZX-Spectrum 48K | Spanish |
| 34681 | Sophia II | ZX-Spectrum 128K | Multi-language: English, French, German, Italian, Portuguese, Russian, Spanish, Swedish |
| 42727 | Sorcerer Kid Adventure | ZX-Spectrum 48K/128K | Multi-language: English, Spanish |
| 28172 | Souls | ZX-Spectrum 48K | Spanish |
| 36534 | Souls Remaster | ZX-Spectrum 48K | Spanish |
| 23759 | Sound Barrier | ZX-Spectrum 48K | English |