| 6951 | The Secret of St. Brides | ZX-Spectrum 48K | English |
| 34999 | The Secretary | SAM Coupé | English |
| 10920 | The Sefton Manor Assignment | ZX-Spectrum 48K | English |
| 12066 | The Sega Collection | ZX-Spectrum 48K | English |
| 19031 | The Seiddab Trilogy | ZX-Spectrum 48K | English |
| 15138 | The Semi-Detached at the End of the Street | ZX-Spectrum 48K | English |
| 4400 | The Sentinel | ZX-Spectrum 48K | English |
| 6955 | The Serf's Tale | ZX-Spectrum 48K | English |
| 34719 | The Servant | ZX-Spectrum 48K | English |
| 20439 | The Settler | ZX-Spectrum 48K | English |
| 19506 | The Seven Cities of Cibola | ZX-Spectrum 16K | English |
| 23036 | The Seven Dwarfs | ZX-Spectrum 48K | English |
| 10181 | The Seven Hills | ZX-Spectrum 16K | English |
| 35207 | The Seven Keys of Tarkus | ZX-Spectrum 48K | English |
| 6958 | The Seven Parchments of Kandos | ZX-Spectrum 48K | English |
| 12470 | The Sewer | ZX-Spectrum 48K | English |
| 4437 | The Shaky Game | ZX-Spectrum 48K | English |
| 42599 | The Shatered World | ZX-Spectrum 48K | English |
| 4463 | The Shoe People | ZX-Spectrum 48K/128K | English |
| 20498 | The Showbiz Quiz | ZX-Spectrum 48K | English |