| 35774 | Sedge Warbloader | ZX-Spectrum 16K | English |
| 39450 | Seduction | ZX81 1K | English |
| 31123 | See How Many Points You Can Score in the Allotted Time | ZX-Spectrum 48K/128K | English |
| 19996 | See It Go + Hit and Run | ZX-Spectrum 48K | English |
| 11022 | See-Saw | ZX-Spectrum 48K | English |
| 26798 | Seed Catcher | ZX-Spectrum 16K | English |
| 41512 | Seek | ZX80 | English |
| 4392 | Seek 'n' Find | ZX-Spectrum 48K | English |
| 22274 | Seek N' Peek | ZX-Spectrum 48K | English |
| 40348 | Seeker | ZX-Spectrum 48K | English |
| 10177 | Seekey | ZX-Spectrum 48K | English |
| 12067 | Sega Master-Mix | ZX-Spectrum 48K | English |
| 30815 | Sega Rally | ZX-Spectrum 16K | English |
| 23169 | Segmental | ZX-Spectrum 48K | English |
| 22707 | Segments | ZX-Spectrum 48K | English |
| 38219 | Seiko RC-1000 Wrist Terminal DATA Manager | ZX-Spectrum 48K/128K | English |
| 38221 | Seiko RC-1000 Wrist Terminal DATA Manager | Sinclair QL | English |
| 40243 | Seikosha GP-250X Screen Copy | ZX-Spectrum 48K | English |
| 25934 | Seikosha GP100A Copy | ZX-Spectrum 48K | English |
| 21246 | Seizure | ZX-Spectrum 48K | English |