| 4643 | Solomon's Key | ZX-Spectrum 48K | English |
| 4645 | Son of Blagger | ZX-Spectrum 48K | English |
| 30412 | Sorceress | ZX-Spectrum 48K | English |
| 30431 | Sorceress 2: The Mystic Forest | ZX-Spectrum 48K | English |
| 14522 | Soul Miner | ZX-Spectrum 128K | English |
| 3457 | Soul of a Robot | ZX-Spectrum 48K | English |
| 31494 | Space Escape | ZX-Spectrum 48K | English |
| 43665 | Space Hopper | ZX-Spectrum 48K | English |
| 37691 | Space Splat | ZX-Spectrum Next | English |
| 15616 | Spaceman Willy | ZX-Spectrum 48K | English |
| 37148 | Spec Kong | ZX-Spectrum 48K | French |
| 44024 | Speccy | ZX-Spectrum 48K | English |
| 27677 | Speccy Bros | ZX-Spectrum 48K | English |
| 38997 | Speccy Quiz | ZX-Spectrum 48K/128K | Multi-language: English, Spanish |
| 4700 | Special Delivery | ZX-Spectrum 48K | English |
| 4708 | Spectral Panic | ZX-Spectrum 16K | English |
| 4746 | Spherical | ZX-Spectrum 48K | English |
| 36479 | Spherical Remastered | ZX-Spectrum 48K/128K | English |
| 4751 | Spike | ZX-Spectrum 48K | English |
| 4772 | Spooked | ZX-Spectrum 48K | English |