| 4310 | Sailing | ZX-Spectrum 48K | English |
| 19731 | Sailing | ZX-Spectrum 16K | English |
| 18542 | Sales | ZX-Spectrum 16K | English |
| 4349 | Satcom | ZX-Spectrum 48K | English |
| 16810 | Save Our Sheep | ZX-Spectrum 16K | English |
| 13223 | Scotrail Class 47 Manager | ZX-Spectrum 48K | English |
| 14057 | Scotrail Express | ZX-Spectrum 48K | English |
| 15854 | Seawolf | ZX-Spectrum 16K | English |
| 29276 | Seawolf | ZX81 16K | English |
| 39450 | Seduction | ZX81 1K | English |
| 17516 | Selectron 36 | ZX-Spectrum 48K | English |
| 14058 | Shedmaster Bounds Green | ZX-Spectrum 48K | English |
| 14059 | Shedmaster Finsbury Park | ZX-Spectrum 48K | English |
| 25936 | Signalman | ZX-Spectrum 48K | English |
| 4502 | Silent Service | ZX-Spectrum 48K | English |
| 4509 | Sim City | ZX-Spectrum 48K/128K | English |
| 43025 | Simulador | ZX-Spectrum 16K/48K | Spanish |
| 35657 | Sinclair Blind Flight Simulator 2009 | ZX81 16K | English |
| 31486 | Slow Cooker Simulator | ZX-Spectrum 48K | English |
| 12406 | Soccer Rematch | ZX-Spectrum 48K | English |