| 6935 | Sea of Zirun | ZX-Spectrum 48K | English |
| 6938 | Search for the Nether Regions | ZX-Spectrum 48K | English |
| 10918 | Seaside Sorcery | ZX-Spectrum 48K | English |
| 32410 | Seastalker - A Junior Adventure (ZxZvm) | ZX-Spectrum 128 +3 | English |
| 35433 | Second Life | ZX-Spectrum 48K | Czech |
| 20487 | Secret Mission | ZX-Spectrum 48K | English |
| 6948 | Secret Mission - 007 James Bond | ZX-Spectrum 48K | Czech |
| 23118 | Secret Mission Radio | ZX-Spectrum 48K | English |
| 20915 | Secuestradores | ZX-Spectrum 48K | Spanish |
| 10176 | Security Shelter | ZX-Spectrum 48K | English |
| 30644 | Sentences | ZX-Spectrum 16K | English |
| 10921 | Serendipity | ZX-Spectrum 48K | English |
| 27383 | Serra Pelada | ZX-Spectrum 48K | Portuguese |
| 10923 | Settlement XIII | ZX-Spectrum 48K | English |
| 26592 | Seven Spanish Angels | ZX-Spectrum 128K | English |
| 15097 | Sex Machine | ZX-Spectrum 48K | English |
| 23521 | SexiMatrix | ZX-Spectrum 128K | Czech |
| 10184 | Sheerluck Holmes and Dr. Witsend | ZX-Spectrum 48K | English |
| 32411 | Sherlock - The Riddle of the Crown Jewels (ZxZvm) | ZX-Spectrum 128 +3 | English |
| 10925 | Sherlock Holmes: A Matter of Evil | ZX-Spectrum 128K | English |