| 23521 | SexiMatrix | ZX-Spectrum 128K | Czech |
| 10184 | Sheerluck Holmes and Dr. Witsend | ZX-Spectrum 48K | English |
| 32411 | Sherlock - The Riddle of the Crown Jewels (ZxZvm) | ZX-Spectrum 128 +3 | English |
| 10925 | Sherlock Holmes: A Matter of Evil | ZX-Spectrum 128K | English |
| 6964 | Sherlock Holmes: The Lamberley Mystery | ZX-Spectrum 48K | English |
| 6967 | Sherlock Holmes: Traja Garridebovia | ZX-Spectrum 48K | Slovak |
| 6970 | Shimmerkin | ZX-Spectrum 48K | English |
| 25452 | Shipwreck | ZX-Spectrum 48K | English |
| 21072 | Shit Game | ZX-Spectrum 48K | English |
| 35918 | Shoddy in Funland | ZX-Spectrum 48K | English |
| 26570 | Shore Leave | ZX-Spectrum 48K | English |
| 18327 | Si da SIDA | ZX-Spectrum 48K | Spanish |
| 32412 | Silence of the Lambs - An Interactive Horror (ZxZvm) | ZX-Spectrum 128 +3 | English |
| 37769 | Silk Dust | ZX-Spectrum 48K | English |
| 38552 | Silkworm | ZX-Spectrum 48K | Portuguese |
| 43948 | Silvestr 2024 | ZX-Spectrum 48K | Czech |
| 10190 | Silvestrovská pecka | ZX-Spectrum 48K | Czech |
| 31079 | Sim City - The Text Adventure | ZX-Spectrum 16K | English |
| 33355 | Sinclair Blind Flight Simulator | ZX-Spectrum 48K | English |
| 32413 | Sins Against Mimesis - An Interactive Theosophy (ZxZvm) | ZX-Spectrum 128 +3 | English |