| 32414 | Slacker X - A Scatological Breakthrough in Adventure Gaming (ZxZvm) | ZX-Spectrum 128 +3 | English |
| 10926 | Sleepin' Again | ZX-Spectrum 128K | English |
| 29637 | Sleeping Beauty | ZX81 1K | English |
| 42785 | Smith IV | ZX-Spectrum 48K | Czech |
| 20505 | Snow Joke | ZX-Spectrum 48K | English |
| 6990 | Snow Joke! | ZX-Spectrum 48K | English |
| 6993 | Snowball | ZX-Spectrum 48K | English |
| 36475 | Snowdrop | ZX-Spectrum 48K | English |
| 32415 | So Far - An Interactive Catharsis (ZxZvm) | ZX-Spectrum 128 +3 | English |
| 10927 | So Little Time | ZX-Spectrum 48K | English |
| 32416 | SoftPorn Adventure - An Interactive Classic (ZxZvm) | ZX-Spectrum 128 +3 | English |
| 36133 | Software Pirate | ZX-Spectrum 48K | English |
| 6997 | Soho Mission | ZX-Spectrum 128K | English |
| 6998 | Soho Sex Quest | ZX-Spectrum 48K | English |
| 6999 | Soho Sex Quest 2: Herpes or Bust | ZX-Spectrum 48K | English |
| 39048 | Soho Sex Quest II | ZX-Spectrum 48K | English |
| 44430 | Solo Dos Deseos | ZX-Spectrum 128 +3 | Spanish |
| 7003 | Something Happened | ZX-Spectrum 48K | Slovak |
| 15232 | Something Happened 2 | ZX-Spectrum 48K | Slovak |
| 7007 | Sorcerer | ZX-Spectrum 48K | English |