| 6994 | Soap Land | ZX-Spectrum 48K | English |
| 7000 | Solaris | ZX-Spectrum 48K | English |
| 7002 | Solvaldol-X | ZX-Spectrum 128K | English |
| 7010 | Sorderon's Shadow | ZX-Spectrum 48K | English |
| 7014 | Souls of Darkon | ZX-Spectrum 48K | English |
| 10928 | Space Detective | ZX-Spectrum 48K | English |
| 10929 | Space Detective II: Home Run | ZX-Spectrum 128K | English |
| 7016 | Space Saving Mission | ZX-Spectrum 48K | Czech |
| 26488 | Spacelord | ZX-Spectrum 48K | Italian |
| 7018 | Spacestation Beta 1 | ZX-Spectrum 48K | English |
| 34980 | SpamCo Adventure | SAM Coupé | English |
| 31174 | Spectrum Blind Flight Simulator 2 - Flying The Plane | ZX-Spectrum 48K | English |
| 44205 | Spider Man: La Ciudad a Oscuras | ZX-Spectrum 128K | Spanish |
| 6855 | Spider-Man | ZX-Spectrum 48K | English |
| 7025 | Spirit of the Demon | ZX-Spectrum 48K | Spanish |
| 35823 | Spooky Tales by Candlelight | ZX-Spectrum Next | English |
| 10235 | Spy Story | ZX-Spectrum 48K | Dutch |
| 7027 | Spytrek Adventure | ZX-Spectrum 48K | English |
| 7034 | Star Crystal | ZX-Spectrum 48K | English |
| 4839 | Star Trip | ZX-Spectrum 48K | English |