| 10928 | Space Detective | ZX-Spectrum 48K | English |
| 10929 | Space Detective II: Home Run | ZX-Spectrum 128K | English |
| 7016 | Space Saving Mission | ZX-Spectrum 48K | Czech |
| 26488 | Spacelord | ZX-Spectrum 48K | Italian |
| 7018 | Spacestation Beta 1 | ZX-Spectrum 48K | English |
| 34980 | SpamCo Adventure | SAM Coupé | English |
| 31174 | Spectrum Blind Flight Simulator 2 - Flying The Plane | ZX-Spectrum 48K | English |
| 44205 | Spider Man: La Ciudad a Oscuras | ZX-Spectrum 128K | Spanish |
| 6855 | Spider-Man | ZX-Spectrum 48K | English |
| 7025 | Spirit of the Demon | ZX-Spectrum 48K | Spanish |
| 35823 | Spooky Tales by Candlelight | ZX-Spectrum Next | English |
| 10235 | Spy Story | ZX-Spectrum 48K | Dutch |
| 7027 | Spytrek Adventure | ZX-Spectrum 48K | English |
| 7034 | Star Crystal | ZX-Spectrum 48K | English |
| 4839 | Star Trip | ZX-Spectrum 48K | English |
| 18920 | Star Wars | ZX-Spectrum 48K | English |
| 7037 | Star Wreck | ZX-Spectrum 48K | English |
| 7045 | Starwash | ZX-Spectrum 48K | Spanish |
| 4890 | Station | ZX-Spectrum 48K | German |
| 34279 | Steamed Hams | ZX-Spectrum 48K | English |