| 43394 | Secrets: The Castle of Doom | ZX-Spectrum 48K | English |
| 30059 | Sector | ZX-Spectrum 48K/128K | English |
| 30148 | Sector: Invasion | ZX-Spectrum 48K/128K | English |
| 31123 | See How Many Points You Can Score in the Allotted Time | ZX-Spectrum 48K/128K | English |
| 26798 | Seed Catcher | ZX-Spectrum 16K | English |
| 41512 | Seek | ZX80 | English |
| 43011 | Segunda Guerra Mundial | ZX-Spectrum 48K | Spanish |
| 44924 | Selva | ZX-Spectrum 16K | Spanish |
| 18445 | Selva Virgen | ZX-Spectrum 48K | Spanish |
| 16191 | Selvaticus | ZX-Spectrum 48K | Spanish |
| 39507 | Seraphima | ZX-Spectrum 128K | English |
| 9411 | Sergeant Seymour Robot Cop | ZX-Spectrum 48K/128K | English |
| 24007 | Serpent | ZX-Spectrum 48K | English |
| 26960 | Serpent | ZX-Spectrum 16K | English |
| 15951 | Serpent's Tail | ZX-Spectrum 48K | English |
| 25438 | Serpents Garden | ZX-Spectrum 48K | English |
| 14851 | Serpes | ZX-Spectrum 48K | Spanish |
| 44905 | Serpiente | ZX-Spectrum 16K | Spanish |
| 41392 | Serve Me! | ZX-Spectrum 16K | English |
| 19162 | Seti 1 | ZX-Spectrum 48K | English |