| 4469 | Short Circuit | ZX-Spectrum 48K/128K | English |
| 4491 | Sideral War | ZX-Spectrum 48K/128K | - |
| 4498 | Sigma 7 | ZX-Spectrum 48K/128K | English |
| 7731 | Signal Part 3 | ZX-Spectrum 48K/128K | English |
| 11350 | Silicon Dreams | ZX-Spectrum 48K/128K | English |
| 4507 | Silkworm | ZX-Spectrum 48K/128K | English |
| 401 | Silver Gun | ZX-Spectrum 48K/128K | Spanish |
| 4509 | Sim City | ZX-Spectrum 48K/128K | English |
| 26201 | Simon | ZX-Spectrum 48K/128K | Spanish |
| 14572 | Simplex | ZX-Spectrum 48K/128K | English |
| 4515 | Simulador Profesional de Tenis | ZX-Spectrum 48K/128K | - |
| 11353 | Sinclair Action Pack - Lightgun Games | ZX-Spectrum 48K/128K | - |
| 39080 | Sinewave 2 | ZX-Spectrum 48K/128K | English |
| 39081 | Sinewave 3 | ZX-Spectrum 48K/128K | English |
| 30170 | Sir Ababol 2 | ZX-Spectrum 48K/128K | Multi-language: English, Spanish |
| 4524 | Sirwood | ZX-Spectrum 48K/128K | Spanish |
| 36952 | Skate Alice | ZX-Spectrum 48K/128K | Russian |
| 4530 | Skate Crazy | ZX-Spectrum 48K/128K | English |
| 10647 | Skate Wars | ZX-Spectrum 48K/128K | English |
| 4536 | Skateball | ZX-Spectrum 48K/128K | English |