| 14572 | Simplex | ZX-Spectrum 48K/128K | English |
| 4515 | Simulador Profesional de Tenis | ZX-Spectrum 48K/128K | - |
| 11353 | Sinclair Action Pack - Lightgun Games | ZX-Spectrum 48K/128K | - |
| 45194 | Sinclair Sketch | ZX-Spectrum 48K/128K | English |
| 39080 | Sinewave 2 | ZX-Spectrum 48K/128K | English |
| 39081 | Sinewave 3 | ZX-Spectrum 48K/128K | English |
| 30170 | Sir Ababol 2 | ZX-Spectrum 48K/128K | Multi-language: English, Spanish |
| 4524 | Sirwood | ZX-Spectrum 48K/128K | Spanish |
| 36952 | Skate Alice | ZX-Spectrum 48K/128K | Russian |
| 4530 | Skate Crazy | ZX-Spectrum 48K/128K | English |
| 10647 | Skate Wars | ZX-Spectrum 48K/128K | English |
| 4536 | Skateball | ZX-Spectrum 48K/128K | English |
| 4541 | Skateboard Kidz | ZX-Spectrum 48K/128K | English |
| 4554 | Skull & Crossbones | ZX-Spectrum 48K/128K | English |
| 9417 | Sky High Stuntman | ZX-Spectrum 48K/128K | English |
| 13050 | Slab Age | ZX-Spectrum 48K/128K | Russian |
| 4562 | Slaine | ZX-Spectrum 48K/128K | English |
| 9418 | Slightly Magic | ZX-Spectrum 48K/128K | English |
| 24427 | Slightly Spooky | ZX-Spectrum 48K/128K | English |
| 23828 | Slubberdegullion | ZX-Spectrum 48K/128K | English |