| 20486 | The Search for Sharla | ZX-Spectrum 48K | English |
| 6940 | The Search for the Wonderful Whotsit | ZX-Spectrum 128K | English |
| 2001015 | The Second Self: Computers and the Human Spirit | - | English |
| 22438 | The Secret City of Kokos Khan | ZX-Spectrum 48K | English |
| 6942 | The Secret Diary of Adrian Mole Aged 13 3/4 | ZX-Spectrum 48K | English |
| 17597 | The Secret River | ZX-Spectrum 48K | English |
| 43706 | The Secret in the Garden | ZX-Spectrum 128K | English |
| 2000321 | The Secret of Arendarvon Castle | - | English |
| 4390 | The Secret of Levitation | ZX-Spectrum 48K | English |
| 6949 | The Secret of Little Hodcome | ZX-Spectrum 48K | English |
| 6951 | The Secret of St. Brides | ZX-Spectrum 48K | English |
| 34999 | The Secretary | SAM Coupé | English |
| 10920 | The Sefton Manor Assignment | ZX-Spectrum 48K | English |
| 12066 | The Sega Collection | ZX-Spectrum 48K | English |
| 19031 | The Seiddab Trilogy | ZX-Spectrum 48K | English |
| 15138 | The Semi-Detached at the End of the Street | ZX-Spectrum 48K | English |
| 4400 | The Sentinel | ZX-Spectrum 48K | English |
| 6955 | The Serf's Tale | ZX-Spectrum 48K | English |
| 34719 | The Servant | ZX-Spectrum 48K | English |
| 20439 | The Settler | ZX-Spectrum 48K | English |