| 19506 | The Seven Cities of Cibola | ZX-Spectrum 16K | English |
| 23036 | The Seven Dwarfs | ZX-Spectrum 48K | English |
| 10181 | The Seven Hills | ZX-Spectrum 16K | English |
| 35207 | The Seven Keys of Tarkus | ZX-Spectrum 48K | English |
| 6958 | The Seven Parchments of Kandos | ZX-Spectrum 48K | English |
| 12470 | The Sewer | ZX-Spectrum 48K | English |
| 4437 | The Shaky Game | ZX-Spectrum 48K | English |
| 42599 | The Shatered World | ZX-Spectrum 48K | English |
| 4463 | The Shoe People | ZX-Spectrum 48K/128K | English |
| 20498 | The Showbiz Quiz | ZX-Spectrum 48K | English |
| 22724 | The Shrink | ZX-Spectrum 48K | English |
| 7065 | The Sidney Affair | ZX-Spectrum 48K | English |
| 28104 | The Siege of Doune Castle | ZX-Spectrum 16K | English |
| 40905 | The Sight of Music | ZX81 16K | English |
| 2000323 | The Silicon Idol | - | English |
| 15073 | The Sillycon War | ZX-Spectrum 48K | English |
| 2001014 | The Simon & Schuster Question & Answer Book, Computers | - | English |
| 4513 | The Simpsons: Bart vs. the Space Mutants | ZX-Spectrum 128K | English |
| 2000326 | The Sinclair Book of Students' Calculations | - | English |
| 2000327 | The Sinclair QDOS Companion: A Guide to the QL Operating System | Sinclair QL | English |